慢性失眠障碍患者的杏仁体休息状态功能连接性改变:与睡眠期间电脑图贝塔功率的相关性
Woojin Kweon1, Kyung Hwa Lee2,3, Sang Ho Choi4
1Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Sleep
|August 2, 2023
概括
患有慢性失眠障碍的患者表现出大脑连接和高兴度生物标志物的改变. 右桃体和左上边缘环之间静止状态功能连接 (RSFC) 的下降与睡眠期间EEGβ功率的增加有关.
科学领域:
- 神经科学是一个神经科学.
- 睡眠医学 睡眠医学
- 精神病学是一个精神病学.
背景情况:
- 慢性失眠障碍 (CID) 与过度兴奋有关.
- 突出网络,包括杏仁体 (AMG) 和前胰岛 (aINS),涉及到过度兴奋.
- 了解CID中静止状态功能连接 (RSFC) 和高兴度生物标志物的变化至关重要.
研究的目的:
- 为了研究RSFC和高兴度生物标志物的变化,与良好的睡眠者 (GS) 相比,在CID患者中研究.
- 检查CID中改变的RSFC和高兴度生物标志物之间的关系.
主要方法:
- 50名患有CID和52名GS的患者接受了多睡眠学,休息状态功能磁共振成像 (fMRI),并填写了问卷.
- 在AMG和aINS中分析了RSFC.
- 过度兴奋的生物标志物包括脑电图 (EEG) 相对β功率和睡眠期间心率变化 (HRV).
主要成果:
- 与GS相比,患有CID的患者在右AMG (R.AMG) 和左上边脊髓 (L.SMG) 之间的RSFC降低.
- 患有CID的患者在左侧aINS和双边侧面前额皮层之间表现出改变的RSFC.
- 在中部地区,R.AMG-L.SMG RSFC与EEGβ功率有负相关性.
结论:
- 在CID中降低R.AMG-L.SMGRSFC可能表明AMG的皮质上下调节受损,这表明白天过度兴奋.
- 失眠的个体在睡眠期间增加EEGβ功率可能反映皮质过度兴奋.
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