环境有机污染物的识别和优先考虑:从分析和毒理学的角度来看
Ting Ruan1,2, Pengyang Li1,2, Haotian Wang1,2
1State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Chemical reviews
|August 2, 2023
概括
识别未知的环境有机污染物对于了解混合物毒性至关重要. 本综述涵盖了先进的分析方法,如非目标查和以效果为导向的分析,以识别这些化学品并评估风险.
科学领域:
- 环境化学环境化学
- 分析化学 分析化学
- 毒理学 毒理学 毒理学
背景情况:
- 环境有机污染物对生态和健康构成重大风险.
- 污染物混合物中未识别的化学成分代表着一个主要的知识差距.
- 了解污染物混合物的综合作用对于风险评估至关重要.
研究的目的:
- 审查认可环境有机污染物的基本原则.
- 描述互补的分析方法和实验平台.
- 讨论非目标查和风险评估的未来方向.
主要方法:
- 量化结构-活动关系 (QSAR) 预测的概述.
- 质谱非目标选技术的描述.
- 效果导向分析 (EDA) 工作流程的解释.
主要成果:
- 分析突破使污染物成分能够更好地识别.
- 审查涵盖了技术开发和污染物识别分析工作流程.
- 讨论了未来的毒性物质识别和风险评估策略.
结论:
- 先进的分析技术对于解决污染物混合物毒性的知识差距至关重要.
- 综合风险评估需要跨学科的方法和勃发展的战略.
- 未来的非目标选方法对识别未知的环境污染物充满希望.
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