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拉脱维亚的甲型肝炎病毒亚基因型,2008-2021年

Oksana Savicka¹, Diana Dusacka², Reinis Zeltmatis²

¹Riga East Clinical University Hospital, Laboratory "Latvian Centre of Infectious Diseases", National Microbiology Reference Laboratory, Riga, Latvia; Riga Stradins University, Department of Infectology, Latvia.

Journal of infection and public health

|August 2, 2023

概括

在拉脱维亚,甲型肝炎病毒 (HAV) 亚基因型IA,IB和IIIA流通,IA病例需要更长的住院时间. 分子和流行病学分析对于了解HAV传播和进口感染至关重要.

科学领域:

病毒学病毒学
流行病学流行病学
公共卫生公共卫生

背景情况:

在拉脱维亚,2008-2010年和2017-2018年发生了甲型肝炎病毒 (HAV) 疫情.
由于卫生惯例不佳,HAV引入和传播的持续风险仍然存在.

研究的目的:

调查拉脱维亚的HAV亚基因型的分子流行病学和传播.
分析与HAV感染相关的人口,临床和流行病学数据.

主要方法:

从259个HAV病例血清样本中对VP1/P2A基因组区域进行测序.
分子遗传学分析以确定HAV集群和国际关系.
收集和分析流行病学数据,包括患者人口统计,症状,住院,疫苗接种状态和潜在的感染源.

主要成果:

HAV亚基因型IA显示13个集群和12个零星病例;IB显示8个集群和11个零星病例;IIIA显示1个集群和9个零星病例.
感染源包括与感染者接触,旅行和高风险群体 (注射药物者,与男性发生性关系的男性).
亚基因型IA感染与最长的住院时间 (平均9.3天) 有关. 疫苗接种情况在很大程度上是未知的或负面的.

结论:

分子和流行病学研究对于了解高血压病毒传播动态至关重要.
这些方法有助于调查本地疫情,检测进口病例和监测病毒循环.
有针对性的公共卫生干预可以通过详细的亚基因型和流行病学数据来告知.

关键词:

在HAV基因型中.甲型肝炎病毒 (HAV)与男性发生性关系的男性 (MSM)疫情爆发的原因是注射毒品的人 (PWID)人类遗传学分析

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