非编码RNAs,癌症治疗和心脏毒性:一个新的希望的三位一体
Rishabh Mittal1, Sarath Krishnan M P1, Rahul Saxena1
1Department of Biochemistry, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 249203, India.
Cancer treatment and research communications
|August 2, 2023
概括
心脏瘤学针对癌症患者和癌症幸存者的心血管疾病 (CVD). 非编码RNAs (ncRNAs) 是癌症治疗期间诊断,治疗和预防心血管疾病的关键.
科学领域:
- 心脏瘤学 - 心脏瘤学
- 分子生物学分子生物学
- 在瘤学瘤学.
背景情况:
- 全球卫生趋势显示,非传染性疾病的增加,包括癌症和心血管疾病 (CVD).
- 预期寿命的增加导致慢性疾病的负担更高,包括癌症幸存者面临心血管并发症.
- 抗癌疗法可能会导致意外的心血管毒性,增加发病率和死亡率.
研究的目的:
- 审查癌症幸存者的心血管后果风险评估.
- 研究非编码RNAs (ncRNAs) 在接受癌症治疗的患者心血管疾病 (CVD) 中的作用.
- 探索ncRNA参与癌症幸存者的心血管疾病的诊断,治疗和预防.
主要方法:
- 综合文献综述. 这是一个全面的文献综述.
- 对癌症幸存者的风险评估策略的评估.
- 在癌症患者中分析ncRNAs和心血管疾病之间的关联.
主要成果:
- 非编码RNAs (ncRNAs) 在心脏瘤学中与心血管疾病 (CVD) 的早期诊断,预后和治疗策略有关.
- 了解ncRNA的作用可以帮助最大限度地减少癌症治疗的心血管副作用.
- 对ncRNA的洞察力可以指导改进诊断,治疗和预防措施的开发.
结论:
- 尽量减少癌症治疗的心血管副作用可以改善患者的治疗结果.
- 在癌症患者的心血管健康管理中,ncRNAs发挥着重要作用.
- 本综述提供了关于癌症和心血管疾病之间的相互作用的见解,以改善患者护理.
相关概念视频
lncRNA - Long Non-coding RNAs
8.6K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
Types of RNA
5.9K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
5.9K
MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
Experimental RNAi
6.2K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.2K
siRNA - Small Interfering RNAs
16.8K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
16.8K
Cancer-Critical Genes II: Tumor Suppressor Genes
7.5K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.5K


