骨肌肉的运动功能由维生素D通过腺三酸盐代谢来调节
Risako Mori1, Megumi Mae2, Hitoki Yamanaka3
1Graduate School of Gastronomy Management, Ritsumeikan University, Kusatsu, Shiga, Japan.
Nutrition (Burbank, Los Angeles County, Calif.)
|August 2, 2023
概括
骨肌中的活性维生素D (1,25(OH) 2D3) 信号传递对于运动功能至关重要. 这项研究表明,维生素D受体 (Vdr) 信号调节肌肉ATP动态,影响身体活动和骨健康.
科学领域:
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
- 运动生理学 运动生理学
背景情况:
- 维生素D内分泌系统对肌肉骨发育和骨通过吸收生长至关重要.
- 活性维生素D (1,25-dihydroxyvitamin D3 [1,25(OH) 2D3]) 在骨健康中起作用,但它对肌肉骨性能的直接影响需要阐明.
研究的目的:
- 确定1,25(OH) 2D3对肌肉组织的直接影响及其在肌肉骨功能中的作用.
- 为了研究1,25(OH) 2D3-VDR信号影响运动功能的机制.
主要方法:
- 在小鼠骨肌中对维生素D受体 (Vdr) 基因的遗传失活化,以评估1,25(OH) 2D3-VDR信号在运动功能的作用.
- 使用培养的C2C12细胞进行体外研究,以评估1,25(OH) 2D3对肌肉发育和ATP动态的直接影响.
主要成果:
- 缺少骨肌中的Vdr的小鼠表现出运动运动活动减少和骨表型受损,包括骨矿物质密度下降和骨质细胞活性增加.
- 在体外,1,25(OH) 2D3治疗改变了细胞ATP动态,通过降低ATP与腺胺单酸盐的比率而不会影响ATP的产生.
- 1,25(OH) 2D3治疗增加了细胞外ATP释放 (通过连xin 43) 和酸盐度,抑制了肌肉细胞中的积累.
结论:
- 骨肌中的1,25(OH) 2D3-VDR信号传递对于维持运动功能至关重要.
- 通过1,25(OH) 2D3-VDR信号调节细胞ATP动态和酸盐代谢,是其对肌肉性能影响的关键机制.
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