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发现了具有高细胞功能的quinazoline HPK1 抑制剂

Momar Toure1, Theresa Johnson1, Bin Li1

  • 1Discovery & Development Technologies, Medicinal Chemistry, EMD Serono Research & Development Institute, Inc., Billerica, MA 01821, United States.

Bioorganic & medicinal chemistry
|August 2, 2023
PubMed
概括

血液生成原体激酶1 (HPK1) 的抑制可以增强抗瘤免疫力. 研究人员使用基于结构的药物设计发现了强大的HPK1抑制剂,显示出显著的细胞活性和IL-2分泌.

关键词:
在HPK1中,HPK1是抑制剂是一种抑制剂.基因酶激酶的使用方法优化优化 优化优化基纳氨酸是什么 基纳氨酸是什么pSLP7676 在线阅读

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