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Updated: Jul 20, 2025

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

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针对选择性化疗的转录复制冲突的小分子向

Long Gu1, Min Li2, Caroline M Li1

  • 1Department of Molecular Diagnostics & Experimental Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA, USA.

Cell chemical biology
|August 2, 2023
PubMed
概括

一个新型的小分子,AOH1996,通过抑制增殖细胞核抗原 (PCNA),选择性地杀死癌细胞,并具有最小的副作用,从而向转录复制冲突.

关键词:
修复DNA的修复DNA的修复DNA复制的压力是DNA复制的压力.这是一个PCNA,PCNA,PCNA.转录-复制冲突发生.

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