太空中的心血管疾病:系统性审查
Chayakrit Krittanawong1, Ameesh Isath2, Scott Kaplin1
1Cardiology Division, NYU Langone Health and NYU School of Medicine, New York, NY, USA.
Progress in cardiovascular diseases
|August 2, 2023
概括
太空旅行会影响心血管健康,导致心脏变化和因微重力而导致静态不耐受性. 太空辐射也可能增加动脉样硬化风险,需要对长期任务进行进一步研究.
科学领域:
- 心血管科学 心血管科学
- 太空医学 太空医学
- 航空航天生理学 航空航天生理学
背景情况:
- 扩大商业太空计划需要了解心血管风险.
- 太空环境暴露 (微重力,辐射) 构成潜在的健康威胁.
- 有限的数据表明,与地球相比,太空中存在独特的心血管挑战.
研究的目的:
- 系统地审查宇航员的心血管结果.
- 综合目前关于太空飞行对心脏影响的证据.
- 识别太空心血管研究中的知识差距.
主要方法:
- 对多个科学数据库 (PubMed,CENTRAL,科学网,EMBASE,Cochrane) 的系统审查.
- 包括关于太空飞行和心血管结果的前性研究.
- 没有日期或语言限制适用于搜索.
主要成果:
- 分析了35项涉及2696名太空旅行者的研究.
- 微重力导致过渡性心脏缩并改变了血液流动.
- 太空辐射在动物模型中显示了与内皮损伤的潜在联系.
- 宇航员经历了静止不耐症和增加的心室外皮.
- 人类数据显示,动脉样硬化疾病没有显著增加,但死亡率数据相矛盾.
结论:
- 太空危险对心血管系统有很大的影响.
- 微重力诱导心脏缩和静态不耐受.
- 太空辐射可能会加速动脉样硬化;对于长期任务来说,进一步的研究至关重要.
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