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与自闭症和精神分裂症相关的SHANK3突变导致发育中的小鼠大脑中状脊柱动态的共同和明显变化

Chengyu Huang¹, Mikayla M Voglewede², Elif Naz Ozsen²

¹Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu, China.

|August 2, 2023

概括

在SHANK3基因突变影响神经发育障碍,如自闭症谱系障碍 (ASD) 和精神分裂症的树突脊柱可塑性. 这项研究揭示了对脊柱结构的共同和独特影响,为突触功能障碍提供了洞察力.

科学领域:

神经科学是一个神经科学.
遗传学是一个遗传学.
发展生物学发展生物学

背景情况:

自闭症谱系障碍 (ASD) 和精神分裂症是不同的神经发育障碍,具有共同的遗传因素和症状.
这两种情况都表现出树突脊柱的异常,这对于激发性突触输入至关重要.
突触支架蛋白Shank3被认为是ASD和精神分裂症的候选基因.

研究的目的:

为了研究患者衍生的SHANK3突变如何影响树突脊柱在大脑发育过程中的结构性可塑性.
为了比较ASD相关 (InsG3680) 和精神分裂症相关 (R1117X) SHANK3突变对树突性脊柱动态的影响.

主要方法:

在小鼠模型中利用实时两光子体内成像.
在与ASD和精神分裂症相关的SHANK3突变的小鼠中检查了树突性脊柱结构可塑性.

主要成果:

在与ASD相关的InsG3680和与精神分裂症相关的R1117X突变小鼠之间,在树突性脊柱形态发生和可塑性中确定了共享和独特的表型.
在任何一种突变小鼠模型中都没有观察到树树木的显著变化.
表明突触失调是以前报告的行为缺陷的潜在贡献者.

结论:

与患者相关的SHANK3突变在大脑发育过程中对树突脊柱动力学产生差异性影响.
研究结果提供了关于突触基础的见解,这些突触基础是ASD和精神分裂症的不同表型的基础.
强调了突触调节在神经发育障碍中的作用.

关键词:

这就是SHANK3的原因.自闭症自闭症是什么树枝状的棘树枝状的棘在活体中成像成像精神分裂症是一种精神分裂症.突触性可塑性突触性可塑性

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