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血清代谢组形状的差异解释了年轻山羊生长表现的个体差异

Dang Dang Wang¹, Guang Fu Tang¹, Yuan Yuan Li¹

¹College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China; Key Laboratory of Livestock Biology, Northwest A&F University, Yangling, Shaanxi 712100, China.

Journal of proteomics

|August 2, 2023

概括

年轻山羊的高生长率与特定的血清代谢物和肠道细菌有关. 识别这些生物标志物,如基和L-histidine,可以提高山羊的生长性能和农场经济.

科学领域:

动物科学动物科学
代谢学代谢学代谢学
微生物组研究微生物组研究

背景情况:

高增长率和体重对于乳山羊的生产力和利能力至关重要.
了解影响生长变化的因素对于优化动物表现至关重要.

研究的目的:

为了确定与年轻山羊的平均每日增益 (ADG) 相关的血清代谢物.
探索血清代谢组概况和消化道微生物群与生长速度之间的关系.
寻找潜在的生物标志物来区分具有高和低生长率的山羊.

主要方法:

选择了99只6个月大的雌性山羊,分为最高 (HADG) 和最低 (LADG) 的平均每日增益组.
分析了HADG和LADG组之间的血清代谢物和消化道微生物群的差异.
利用途径分析和斯皮尔曼等级相关性来识别关键代谢物及其与ADG和细菌的关联.

主要成果:

在HADG和LADG山羊之间确定了125种显著不同的血清代谢物.
发现了不同的代谢物概况,HADG山羊显示了较高水平的氨基酸相关代谢物 (例如L-histidine,hydroxylysine),LADG山羊显示了较高水平的其他代谢物 (例如P-酸).
在不同血清代谢物,ADG和特定的肠道细菌之间建立了相关性;基和L-histidine在区分生长群体时显示了>92.0%的准确性.

结论:

肠道微生物群和血清代谢组的个体差异显著导致年轻山羊的生长率变化.
特定的血清代谢物,如基和L-histidine,可以作为生长表现的有效生物标志物.
研究结果为营养策略提供了洞察力,以提高山羊产业的增长和效率.

关键词:

消化道的微生物群一只山羊是一只山羊.增长率的增长速度是什么血清代谢组是血清代谢组中的一个.

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