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Hsa_circ_0003098通过miR-377-5p/ACAT2轴促进了膀癌的进展

Yidong Cheng¹, Hao Yu², Kai Li²

¹Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 21000, Jiangsu Province, PR China; Department of Urology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing 21000, Jiangsu Province, PR China.

|August 2, 2023

概括

循环RNAs (circRNAs) 在瘤进展中至关重要. 这项研究揭示hsa_circ_0003098通过通过海绵miR-377-5p调节ACAT2,促进膀癌 (BCa) 的生长,表明其致癌作用.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物化学生物化学

背景情况:

循环RNAs (circRNAs) 越来越多地被认为是它们在癌症发展中的作用.
膀癌 (BCa) 中circRNAs的特定功能和机制尚未完全理解.

研究的目的:

为了研究hsa_circ_0003098在膀癌中的作用.
阐明hsa_circ_0003098影响BCa进展的分子机制.

主要方法:

分析BCa组织中的hsa_circ_0003098表达和与预后的相关性.
在体外和体外功能测试以评估hsa_circ_0003098对BCa细胞行为和瘤生长的影响.
涉及miRNA海绵化 (miR-377-5p) 和目标基因 (ACAT2) 调节的机制研究.

主要成果:

hsa_circ_0003098表达在BCa组织中显著上调,并与预后不佳有关.
过度表达hsa_circ_0003098增强BCa细胞的增殖,迁移,入侵,以及体内瘤的生长.
hsa_circ_0003098 作为miR-377-5p的分子海绵,导致ACAT2表达增加和胆固醇积累.

结论:

hsa_circ_0003098 在膀癌中作为瘤基因起作用.
hsa_circ_0003098是一个潜在的诊断生物标志物和BCa的治疗目标.

关键词:

在ACAT2中使用ACAT2.膀癌是一种癌症.hsa_circ_000309898 这是一个很好的例子.在 miR-377-5p 中使用.

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