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基于AIEgen的共价有机框架,通过局部高温疗法预防恶性心室失常

Liang Zhang^1,2,3, Fuding Guo², Saiting Xu²

¹Department of Chemistry and The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, 999077, China.

Advanced materials (Deerfield Beach, Fla.)

|August 2, 2023

概括

新的共价有机框架 (COF) 作为高热剂来治疗心室失常症 (VAs). 这些药物调节星状质活动并减少炎症,提供对心脏事件的双重保护.

科学领域:

材料科学材料科学材料科学
生物医学工程生物医学工程
心脏病学心脏病学

背景情况:

恶性心室节律失常 (VAs) 是一个重大的临床挑战.
目前对VA的治疗方法往往具有局限性和副作用.
准星状 (SG) 和其周围的神经炎症是VA抑制的有希望的策略.

研究的目的:

设计基于聚合诱导排放光原体 (AIEgen) 的新型共价有机框架 (COFs) 作为高温剂.
调查这些AIE COFs在调节 SG活动和改善围绕 SG的微环境中的双重功能.
评估这些AIE COFs在抑制缺血引起的VAS中的有效性.

主要方法:

基于AIEgen的COFs (TDTA-COF,BTDTA-COF,BTDBETA-COF) 的合成和表征.
在体内使用BTDBETA-COF进行针对SG的局部高温疗法 (LHT) 的研究.
围绕SG脂肪组织的转录组分析,以评估基因表达和炎症标志物.

主要成果:

通过LHT,AIE COFs在调节SG功能和神经活动方面表现出双重功能.
在体内,BTDBETA-COF介导的LHT增强了发热和与色相关的基因表达.
转录组分析显示,SG周围脂肪组织中的炎症性细胞因子显著下调,表明神经炎症有所改善.
通过BTDBETA-COF介导的LHT提供了心肌和心律失常的保护.

结论:

设计的AIE COF作为有效的高热剂,可以抑制VA.
AIE COFs对SG调节和神经炎症减轻的双重作用提供了一个新的治疗策略.
这种方法为缓解心交感神经过活性的新途径提供了新的途径,并预防VA.

关键词:

一个AIEgen的人.共价有机框架是共价有机框架.过热剂是一种高热剂.恶性心室心律不整.通过神经调节进行神经调节.

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