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Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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APOBEC3B诱导的突变发生的遗传抑制剂

Tony M Mertz1,2, Elizabeth Rice-Reynolds3, Ly Nguyen3

  • 1School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, Washington 99164, USA; tony.mertz@wsu.edu steven.roberts2@wsu.edu srober23@uvm.edu.

Genome research
|August 2, 2023
PubMed
概括

确定了影响癌症APOBEC3B诱导突变的遗传因素. 缺乏BRCA1/2的乳腺癌显示出增加的APOBEC突变,与DNA复制和修复途径有关.

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