托塞拉尼布酸盐和费罗可西布介导的部分反应在一个狗的先进的鼻内肉瘤
Hironari Osada1, Taiga Okazawa2, Kazuya Kushida1
1Animal Medical Center, Tokyo University of Agriculture and Technology, Tokyo, Japan.
The Journal of veterinary medical science
|August 2, 2023
概括
一个病例报告详细介绍了一种用托塞拉尼布酸盐 (TOC) 和firocoxib治疗的狗鼻内肉瘤. 这种组合疗法实现了部分瘤反应和延长存活时间,这表明这种罕见的癌症的潜在治疗选择.
科学领域:
- 兽医瘤学 兽医瘤学
- 狗癌症研究 狗癌症研究
- 手术病理学手术病理学
背景情况:
- 鼻内肉瘤是一种罕见的,在狗中具有攻击性的瘤.
- 诊断通常涉及先进的成像和组织病理学.
- 对于狗鼻内肉瘤,有效的治疗选择有限.
研究的目的:
- 报告一例狗鼻内肉瘤病例.
- 为了评估托塞拉尼布酸盐 (TOC) 和费罗可西布治疗的疗效.
- 评估治疗反应和生存结果.
主要方法:
- 计算机断层扫描 (CT) 用于诊断和分期.
- 组织病理学和免疫组织化学分析用于瘤特征.
- 用TOC和firocoxib治疗,然后用TOC单独治疗.
主要成果:
- 扫描显示左鼻腔质量与cribriform盘溶解.
- 免疫组织化学证实了具有特定受体表达的肉瘤.
- 联合TOC和firocoxib实现了部分反应 (PR).
- 在PR诱导后的TOC单疗导致205天的生存.
结论:
- 托塞拉尼布酸盐 (TOC) 与费罗可西布相结合,对治疗犬类鼻内瘤有望.
- 这种组合可能会诱导瘤回归并改善存活率.
- 需要对这种治疗方法进行进一步的研究.
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