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Updated: Jul 20, 2025

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
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Published on: October 18, 2024

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普罗格拉努林对通过自解酶体形成减少α-synuclein的参与

Honoka Fujimori1, Takuya Ohba1, Shinsuke Nakamura1

  • 1Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University.

Biological & pharmaceutical bulletin
|August 2, 2023
PubMed
概括

普格拉努林 (PGRN) 可能通过增强α-synuclein (α-Syn) 清除来治疗帕金森病 (PD). 在PD模型中,PGRN增强了自-溶解体通路,减少α-Syn积累,改善PD模型中的运动功能.

关键词:
帕金森病是帕金森氏症的一种疾病.自自是自的过程.lysosome 溶解酶体是如何形成的益格拉努林是一种前列腺素.α-synuclein 是一种同核蛋白.

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