慢性四肢威胁性缺血是患有下肢动脉疾病的患者中残留出血的危险因素
Takahiro Tokuda1, Naoki Yoshioka2, Akio Koyama3
1Department of Cardiology, Nagoya Heart Center.
Journal of atherosclerosis and thrombosis
|August 2, 2023
概括
慢性四肢威胁性缺血 (CLTI) 是患有下肢动脉疾病 (LEAD) 的患者进行内血管治疗 (EVT) 的出血的重要预测因素. 在EVT后对CLTI患者的出血事件进行仔细监测至关重要.
科学领域:
- 血管外科 血管外科
- 干预心脏病学 干预心脏病学
- 患者安全 患者安全
背景情况:
- 下肢动脉疾病 (LEAD) 是出血并发症的已知危险因素.
- 需要进一步阐明LEAD患者内血管治疗 (EVT) 后出血的特定危险因素.
研究的目的:
- 识别和分析经过EVT的被诊断为LEAD的患者出血的风险因素.
- 专门调查慢性四肢威胁性缺血 (CLTI) 作为出血风险因素的作用.
主要方法:
- 这是一项多中心,回顾性,观察性研究,涉及732名接受EVT的LEAD患者.
- 患者特征,实验室数据,病变细节和CLTI和无CLTI患者之间的药物比较.
- 考克斯回归分析的应用,以确定预测性出血风险因素.
主要成果:
- 体重不足 (BMI <18.5 kg/m2),先前心力衰竭,高出血风险和抗血小板/华法林联合治疗是出血显著预测因素.
- 贫血,低血小板计数,慢性病和CLTI被确定为EVT后出血的独立危险因素.
- 发现CLTI是出血事件的一致且显著的预测因子.
结论:
- 慢性四肢威胁性缺血症 (CLTI) 是EVT后LEAD患者出血的关键残留和预测风险因素.
- 增加警和监测出血并发症对于在EVT后患有CLTI的患者至关重要.
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