在婴儿中发现的意外抗体的临床意义和分布
Han Joo Kim1, Suk Won Seo1, Yousun Chung2
1Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
概括
婴儿中意想不到的抗体检测揭示了不同的模式,最常见的是抗M. 考虑到母性因素的仔细解释对于在这个人群中诊断胎儿和新生儿 (HDFN) 溶血性疾病至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 输血医学 输血医学
- 儿科 儿科 儿科
背景情况:
- 意想不到的抗体检测对于输血安全至关重要.
- 婴儿具有不成熟的抗原/抗体系统,需要不同的输血前测试和策略.
- 了解婴儿的抗体模式对于安全的输血实践至关重要.
研究的目的:
- 分析婴儿中意外抗体的患病率和模式.
- 评估这些抗体的临床意义,特别是与胎儿和新生儿血溶性疾病 (HDFN) 相关.
- 为了比较婴儿的抗体模式与通常在成年人中观察到的抗体模式.
主要方法:
- 对一岁以下婴儿进行的意外抗体鉴定测试的回顾性分析.
- 在阿桑医疗中心从1999年到2022年收集的数据.
- 包括患者临床信息,抗体识别结果和母体抗体表型.
主要成果:
- 总共分析了45个意外抗体结果的病例.
- 抗体在4个月以下的婴儿 (25例) 中更为普遍,其中76%与HDFN相关.
- 抗M是最常见的意外抗体 (17例),其中有一个严重的HDFN病例. 在10例病例中发现了抗-E和抗-c的同时出现,其中9例与HDFN有关.
结论:
- 婴儿中意想不到的非ABO抗体模式与成年人群不同.
- 孕产妇检测结果和婴儿临床状况对于解释由于高血压风险而引起的意外抗体检测至关重要.
- 这项研究提供了关于韩国婴儿意外抗体分布和临床意义的第一个全面数据.
更多相关视频
08:12Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets
Published on: September 6, 2019
7.2K
09:08Developing a Salivary Antibody Multiplex Immunoassay to Measure Human Exposure to Environmental Pathogens
Published on: September 12, 2016
8.8K
相关概念视频
01:22Development of Immunocompetence
345
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
345
01:15Transcytosis of IgG
2.8K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.8K
01:36Humoral Immune Responses
73.0K
Overview
73.0K
01:10Antibody Structure
60.3K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.3K
01:19Rh Blood Group
1.6K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.6K
00:42Cross-reactivity
31.3K
Overview
31.3K