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Updated: Jul 20, 2025

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

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一个C/ebpα异型在不朽化髓细胞中的特定分化程序

Maria-Paz Garcia-Cuellar1, Selin Akan1, Robert K Slany2

  • 1Department of Genetics, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.

Leukemia
|August 2, 2023
PubMed
概括

CCAAT增强剂结合因子α (C/ebpα) 异型p42和p30结合方式相同,但诱导不同的转录反应. p42选择性地诱导EGR1和Trib1,影响骨髓细胞分化和信号在急性骨髓细胞白血病.

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Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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