泌尿生长分化因子15预测糖尿病病的功能下降
Toma Oshita1, Shun Watanabe1,2, Takafumi Toyohara3,4,5
1Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Scientific reports
|August 2, 2023
概括
尿路生长分化因子15 (GDF15) 显示为慢性病 (CKD) 的生物标志物具有前途. 这种尿路标记物,与血GDF15不同,对功能的影响较小,可以预测糖尿病病 (DKD) 的疾病进展.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物发现发现
- 线粒体疾病 线粒体疾病
背景情况:
- 敏感的生物标志物对于治疗慢性病 (CKD),包括糖尿病病 (DKD) 至关重要.
- 血生长分化因子15 (GDF15) 是线粒体疾病的生物标志物,但由于与功能下降的相关性,其在CKD中的实用性有限.
- 尿路GDF15被探索为潜在的CKD生物标志物,不太依赖功能.
研究的目的:
- 研究尿液GDF15作为CKD和糖尿病病 (DKD) 的生物标志物的潜力.
- 为了比较尿液GDF15-肌素比与血GDF15与功能和尿液毒素的关系.
- 评估尿液GDF15-肌素比率对DKD患者功能下降的预测值.
主要方法:
- 在103名CKD患者的血和尿液GDF15和15尿性毒素的测量.
- 分析尿液GDF15-肌素比率与临床特征之间的关系,包括功能和尿液毒素.
- 对DKD队列 (U-CARE,n=342) 的回顾性分析,以评估2年间尿液GDF15-肌素基线比率预测能力,以估计膜过率 (eGFR) 的下降.
主要成果:
- 与血GDF15.15相比,尿液GDF15-肌素比率与功能和尿液毒素的相关性较小.
- 在糖尿病慢性病患者中,尿液中的GDF15-肌素比率显著更高,在治疗他类药物时降低.
- 基线尿液GDF15-肌素比率预测了DKD队列的eGFR在2年内下降.
结论:
- 尿液GDF15-肌素比率是CKD,特别是DKD的一个有前途的生物标志物,因为它不受功能的影响.
- 这种尿路标记物反映了与糖尿病和他类药物治疗相关的疾病活性.
- 尿液GDF15-肌氨酸比率可以作为DKD中功能下降的有价值的预后标志物,与尿液白蛋白-肌氨酸比率相比较.
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