Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

630
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
630
Long-term Potentiation01:25

Long-term Potentiation

2.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
2.8K
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.4K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.4K
Storage01:23

Storage

105
A schema is a mental framework that helps individuals organize and interpret information. Schemata, formed from previous experiences, influence how we process new information: how we encode it, the inferences we make, and how we retrieve it. For instance, a schema for what a typical classroom looks like might include desks, a teacher's desk, a whiteboard, and students in such an environment. This expectation helps us quickly understand and navigate new classrooms without needing to analyze...
105
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

877
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
877
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

328
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
328

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Lesion network localization of depression in multiple sclerosis.

Nature. Mental health·2026
Same author

Exploring the relationship between everyday functioning and cognitive performance in individuals with late onset unexplained epilepsy.

Epilepsia·2026
Same author

Atrophy in preclinical Alzheimer's disease maps to a network that predicts longitudinal decline.

Molecular psychiatry·2026
Same author

Comparison of brain normalization software and lesion compensation techniques in chronic perinatal stroke imaging.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Apathy and resting state functional connectivity across the Alzheimer's disease continuum.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

A prognostic human brain network for diffuse midline glioma.

Nature·2026

相关实验视频

Updated: Jul 20, 2025

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.5K

多发性硬化病变会损害记忆,将记忆映射到连接的记忆电路中.

Isaiah Kletenik1,2,3,4, Alexander L Cohen5,6,7,8, Bonnie I Glanz9

  • 1Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, 60 Fenwood Road, 9016H, Boston, MA, 02115, USA. ikletenik@bwh.harvard.edu.

Journal of neurology
|August 2, 2023
PubMed
概括

多发性硬化症 (MS) 的记忆功能障碍与特定大脑电路中的白质病变有关,而不仅仅是整体病变负担. 对这种记忆电路的损伤完全解释了损伤体积和记忆障碍之间的关系.

关键词:
损伤网络绘制地图记忆 记忆 记忆 记忆 记忆多发性硬化症是多发性硬化症.白质病变的病变是白质病变.功能磁力共振成像 (fMRI) 是一种

更多相关视频

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

4.8K
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.0K

相关实验视频

Last Updated: Jul 20, 2025

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.5K
Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

4.8K
Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla
08:51

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

9.0K

科学领域:

  • 神经科学是一个神经科学.
  • 神经学 神经学
  • 医疗成像医学成像

背景情况:

  • 多发性硬化症 (MS) 影响近100万美国人,其中30-50%的人经历记忆功能障碍.
  • 与MS相关的记忆功能障碍的神经解剖学基础仍然不清楚,争论的是它是否源于整体白质病变负载或特定的结构损伤.

研究的目的:

  • 研究MS患者特定神经解剖学回路中的白质病变与记忆功能障碍之间的关联.
  • 为了确定MS记忆功能障碍是否与特定的大脑电路有关,而不是扩散白质损伤.

主要方法:

  • 从431名多发性硬化患者的结构性MRI和口头记忆得分的横截面分析.
  • 使用经过验证的算法绘制白质病变位置的地图.
  • 测试记忆功能障碍与病变总量之间的关联,以及病变与预定义的记忆电路的交叉点.
  • 使用介导分析和数据驱动分析与功能和结构连接组来识别MS记忆电路.

主要成果:

  • 在预定义的记忆电路内,总损伤量和损伤损伤都与记忆功能障碍相关.
  • 记忆电路的损伤完全介导了总损伤体积和记忆性能之间的关系.
  • 数据驱动的分析确定了关键的大脑区域,包括海马体,准海马体,体和带体,与记忆功能障碍相关,与预定义的电路保持一致.

结论:

  • 与MS相关的记忆功能障碍与以海马为中心的特定大脑电路内的白质病变有关.
  • 这种海马中心电路的损伤完全解释了整体损伤体积对记忆的影响.
  • 使用标准MRI的基于电路的方法可能有助于定位和预测MS中高阶认知缺陷.