在一个造血干细胞移植单元中,COVID-19 omicron 变异爆发
Andrea Gilioli1, Paola Bresciani2, Erica Franceschini3
1Section of Hematology, Department of Medical and Surgical Sciences, Azienda Ospedaliero-Universitaria di Modena, University of Modena and Reggio Emilia, Via Del Pozzo, 71, 41124, Modena, MO, Italy. gilioli.andrea@aou.mo.it.
International journal of hematology
|August 2, 2023
概括
这项研究报告了在骨髓移植 (BMT) 单位中管理SARS-CoV-2 Omicron变种感染的情况. 积极的结果表明PCR阴性可能不必在BMT之前对高风险的血液病患者治疗感染.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 移植医学 移植医学 移植医学
背景情况:
- 在血液病患者中,SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 管理是具有挑战性的,因为变种不断演变,早期治疗选择有限.
- 之前对血液恶性瘤的SARS-CoV-2的研究,包括干细胞移植接受者,早于Omicron激增,报告了高死亡率.
研究的目的:
- 描述SARS-CoV-2 Omicron变种在骨髓移植 (BMT) 单位中爆发的特征,临床过程和结果.
- 详细说明在疫情爆发期间在BMT病房使用的非标签治疗和管理策略.
主要方法:
- 在接受骨髓移植的患者中,对SARS-CoV-2 Omicron变异感染的回顾性分析.
- 描述BMT部门实施的感染管理协议,重点关注患者的治疗结果和保护未感染的住院患者.
主要成果:
- 该研究详细介绍了首次报告的SARS-CoV-2 Omicron变种在 BMT 单位的爆发情况.
- 感染在病房内得到管理,使用非标签治疗来优化结果,同时最大限度地降低对其他患者的风险.
- 在接受治疗的感染患者中观察到积极的结果,即使持续的SARS-CoV-2 PCR阳性.
结论:
- 在BMT环境中,可以有效地管理SARS-CoV-2 Omicron变异感染.
- 这些发现表明,在BMT之前实现SARS-CoV-2 PCR阴性可能不是对已接受感染治疗的高风险血液病患者的绝对要求.
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