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相关概念视频

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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相关实验视频

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一个基于微CT的平台来量化药物向.

Brandon J Ausk1, Adam N Tucker2, Philippe Huber2

  • 1In Situ Therapeutic Solutions Inc, Seattle, USA. brandon.ausk@istherasol.com.

European radiology experimental
|August 2, 2023
PubMed
概括
此摘要是机器生成的。

分布剂量注射甲型肉毒素 (BTxA) 显著改善软组织药物覆盖率,而不是单一的注射. 这种微型计算机断层扫描 (microCT) 成像平台可以进行精确的量化,以优化异型骨化预防.

关键词:
药物输送系统是药物输送系统.整形外科 整形外科 整形外科骨化 (异种类型)子子子子在X射线显微断层图像上.

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科学领域:

  • 生物医学工程 生物医学工程
  • 肌肉骨研究 研究
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 异型骨化 (HO) 是肌肉骨创伤和手术后的常见并发症.
  • 预防性治疗的准确分配,如毒素A型 (BTxA),对于有效的HO抑制至关重要.
  • 目前的方法缺乏精确的量化软组织中药物分布.

研究的目的:

  • 开发和验证一种高分辨率成像策略,用于评估软组织中药物分布.
  • 为了比较分布式剂量与单一玻尿酸注射药物输送的疗效.
  • 克服BTxA在HO预防中的临床转化障碍.

主要方法:

  • 使用含有的对比剂的微型计算机断层扫描 (microCT) 来图像化子肌肉中的药物分布.
  • 开发了一个3D打印的软组织支架,以促进受控注射.
  • 在基于接近注射液的基础上,在定义的兴趣体积 (VOI) 内的量化药物覆盖.

主要成果:

  • 微CT方法使得注射分布的高分辨率量化成为可能.
  • 通过原型系统分配剂量实现了显著更高的VOI覆盖率 (72%),而不是单一玻尿酸注射 (43%).
  • 分布剂量也提高了注射准的精度.

结论:

  • 微计算机断层扫描 (microCT) 是一种精确的方法,用于量化软组织中药物分布.
  • 分布剂量策略对于最大限度地覆盖目标软组织体积中的药物是必不可少的.
  • 开发的成像平台有助于快速优化用于预防HO的临床设备的注射参数.