协同作用和氧气适应用于下一代益生菌的开发
Muhammad Tanweer Khan1,2, Chinmay Dwibedi1,3, Daniel Sundh4
1Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
Nature
|August 2, 2023
概括
下一代益生菌现在可以从严格无氧的肠道细菌像Faecalibacterium prausnitzii开发出来. 这项突破涉及使这些微生物适应氧气, 实现新的肠道健康疗法.
科学领域:
- 微生物学
- 胃肠病学
- 益生菌
背景情况:
- 人的肠道微生物群对健康和疾病有很大影响.
- 严格的无氧细菌,如Faecalibacterium prausnitzii,对于肠道健康至关重要,但作为益生菌很难配制.
- 下一代益生菌旨在调节肠道微生物群以改善健康结果.
研究的目的:
- 开发一种从纯无氧细菌生产下一代益生菌的方法.
- 调查Faecalibacterium prausnitzii和Desulfovibrio猪的联合分离和交叉养情况.
- 为了使F. prausnitzii适应氧气耐受性而不会损害有益的特性.
主要方法:
- 同时隔离F. prausnitzii和Desulfovibrio猪.
- F. prausnitzii适应氧气暴露的情况
- 通过临床试验评估共生产品的耐受性和检测性 (NCT03728868).
主要成果:
- 成功共隔离F. prausnitzii和D. piger之间的交叉养,增强生长和酸盐的产生.
- 开发了一种适用于益生菌配方的耐氧F. prausnitzii菌株.
- 概念验证研究证实这种共生产品能很好地被老鼠和人类容忍,并且可以在人体肠道中检测到.
结论:
- 一项新技术可以从纯无氧肠道细菌中生产下一代益生菌.
- 这种方法克服了益生菌发育的氧气敏感性限制.
- 这项技术有可能将其他无氧菌株开发为有效的下一代益生菌.
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