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认知能力下降和增加中性粒细胞-淋巴细胞和血小板-淋巴细胞比率与更高剂量的抗精神病药物在精神分裂症妇女:一个横截面研究
Ilgner Justa Frota1, Alissandra Lima Barbosa de Oliveira2, David Nunes De Lima3
1Neuropsychopharmacology and Translational Psychiatry Laboratory, Drug Research and Development Center, Faculty of Medicine, Federal University of Ceará, Rua Coronel Nunes de Melo, 1000 - Rodolfo Teófilo, Fortaleza, CE, Postal Code 60430-275, Brazil. ilgner0@gmail.com.
在患有精神分裂症的女性中,较高的抗精神病剂量与炎症标志物和较差的认知功能相关,特别是工作记忆. 这些关联在男性中没有观察到,这表明性别特异性影响.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 精神分裂症是一种复杂的精神障碍,影响认知功能.
- 像NLR,MLR和PLR这样的炎症标志物可能在精神分裂症病理生理学中发挥作用.
- 抗精神病药物剂量是管理精神分裂症症状的关键因素.
研究的目的:
- 研究男性和女性精神分裂症患者的炎症标志物,认知表现和抗精神病剂量之间的关系.
- 为了确定性别是否影响炎症,认知和抗精神病治疗之间的关联.
- 探索精神分裂症认知变化的潜在炎症机制.
主要方法:
- 全血清和神经心理测试结果的横截面分析.
- 使用Welch t测试进行群组比较和Pearson测试进行相关性.
- 使用中性粒细胞与淋巴细胞比率 (NLR),单细胞与淋巴细胞比率 (MLR) 和血小板与淋巴细胞比率 (PLR) 测量炎症.
主要成果:
- 与男性相比,精神分裂症女性中中性粒细胞与淋巴细胞的比率 (NLR) 和血小板与淋巴细胞的比率 (PLR) 较高.
- 在女性中,NLR和PLR与抗精神病剂量正相关,与工作记忆相反相关 (直接数字间隔).
- 较高的抗精神病剂量与女性工作记忆,语义记忆和心理灵活性的恶化有关.
结论:
- 精神分裂症妇女的抗精神病治疗与炎症标志物增加和认知能力下降有关.
- 高剂量的抗精神病药物对认知能力的恶化是女性患者特有的.
- 炎症机制可能会调解抗精神病剂量对精神分裂症妇女认知功能的负面影响.
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