患有的成年人生活质量的决定因素:来自德国的多中心,横截面研究

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Kai Siebenbrodt^1,2, Laurent M Willems^3,4, Felix von Podewils⁵

¹Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Goethe-University and University Hospital Frankfurt, Frankfurt am Main, Germany. kai.siebenbrodt@kgu.de.

Neurological research and practice

|August 2, 2023

概括

患者的生活质量受到发作频率以外的因素的显著影响,包括不良事件,抑郁症,耻辱和发作担忧. 解决这些心理行为方面的问题对于优化患者治疗至关重要.

科学领域:

神经学神经学
精神病学是一个精神病学.
生活质量研究研究生命质量研究

背景情况:

评估生活质量 (QoL) 对等慢性神经疾病至关重要.
显著影响患者的生活质量和家庭的福祉,往往被医疗保健提供者低估.
在患有的成年人中确定影响QoL的因素对于综合护理至关重要.

研究的目的:

确定影响成人患者生活质量的关键因素.
了解,治疗副作用和心理健康之间的关系.

主要方法:

这是一项涉及德国476名成年患者的横截式多中心研究.
标准化问卷评估了QOL (QOLIE-31) 和相关方面的质量.
单变量和多变量回归分析确定了降低QoL的显著预测因素.

主要成果:

低QOL与利物浦不良事件概况 (LAEP),医院焦虑和抑郁量表 - 抑郁症子量表 (HADS-D) 和神经障碍性抑郁症库存 (NDDI-E) 的更高得分有显著关联.
增加发作频率,的耻辱 (修订的耻辱度表) 和的担忧 (担忧度表) 也与降低的QOL相关.
多变量分析证实了这些关联,突出了症中QoL的多因素性质.

结论:

患者经历了由疾病严重程度,药物耐受性,抑郁症,耻辱感和对发作的恐惧影响而降低的QoL.
伴随性抑郁症似乎被诊断不足;建议主动查不良事件,抑郁症,恐惧和耻辱感.
考虑到心理行为和疾病特异性因素的个性化治疗策略对于优化护理和改善患者生活质量至关重要.

关键词:

抗发作药物抗发作药物抑郁症抑郁症抑郁症是一种病.这就是QOLIE-31的原因.生活质量生活的质量.发作发作发作

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