Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Wilcoxon Signed-Ranks Test for Matched Pairs01:09

Wilcoxon Signed-Ranks Test for Matched Pairs

164
The Wilcoxon signed-rank test for matched pairs evaluates the null hypothesis by combining the ranks of differences with their signs. It essentially tests whether the median of the differences in a population of matched pairs is zero. Since the test incorporates more information than the sign test, it generally yields more trustable conclusions. This test also does not require the data to follow a normal distribution, but two conditions must be met for it to be applicable: (1) the data must...
164
Sign Test for Matched Pairs01:17

Sign Test for Matched Pairs

162
The sign test for matched pairs offers a robust method for comparing two paired samples, often for the effects of an intervention in one of them. This method is very useful in situations where the underlying distribution of the data is unknown. The test compares two related samples—often pre- and post-treatment measurements on the same subjects—to determine if there are significant differences in their median values.
To conduct the sign test, we first calculate the differences in...
162
Randomized Experiments01:13

Randomized Experiments

7.0K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
7.0K
Improving Translational Accuracy02:07

Improving Translational Accuracy

11.6K
Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
11.6K
Equivalent Couples01:28

Equivalent Couples

307
In mechanical engineering, the concept of equivalent couples plays a crucial role in understanding and analyzing various mechanical systems.
Two couples are considered to be equivalent if they produce the same rotational effect on a rigid body. In other words, the two couples have the same magnitude and act in the same direction, causing the same angular displacement or acceleration in the body.
For instance, consider two couples lying in the plane of the page, with one having a pair of equal...
307
The Representativeness Heuristic02:13

The Representativeness Heuristic

15.8K
The representative heuristic describes a biased way of thinking, in which you unintentionally stereotype someone or something. For example, you may assume that your professors spend their free time reading books and engaging in intellectual conversation, because the idea of them spending their time playing volleyball or visiting an amusement park does not fit in with your stereotypes of professors.
15.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Matching with Multiple Criteria and Its Application to Health Disparities Research.

Observational studies·2026
Same author

Determining vaccine responders in the presence of baseline immunity using single-cell assays and paired control samples.

Biostatistics (Oxford, England)·2025
Same author

Neutralizing and binding antibodies are a correlate of risk of COVID-19 in the CoVPN 3008 study in people with HIV.

Nature communications·2025
Same author

Mapping the expression of endothelial adhesion receptors for Plasmodium falciparum-infected erythrocytes in fatal cerebral malaria in Malawian children.

Journal of neuropathology and experimental neurology·2025
Same author

Electroencephalogram Features Distinguish Cases of Cerebral Malaria Among Malawian Children With Fever and Coma.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same author

Negative Control Outcome Adjustment in Early-Phase Randomized Trials: Estimating Vaccine Effects on Immune Responses in HIV Exposed Uninfected Infants.

Statistics in medicine·2025
Same journal

Fast penalized generalized estimating equations for large longitudinal functional datasets.

Biometrics·2026
Same journal

Causally-interpretable random-effects meta-analysis.

Biometrics·2026
Same journal

Statistical inference for mean function of partially observed functional time series.

Biometrics·2026
Same journal

Subgroup identification via Interaction Tree and Mixed Model for Repeated Measures with application to Alzheimer's disease.

Biometrics·2026
Same journal

Finite mixtures of linear quantile regressions with concomitant variables: a solution to endogeneity in longitudinal data modeling.

Biometrics·2026
Same journal

Discussion on "INTACT: a method for integration of longitudinal physical activity data from multiple sources" by Jingru Zhang, Erjia Cui, Hongzhe Li, and Haochang Shou.

Biometrics·2026
查看所有相关文章

相关实验视频

Updated: Jul 20, 2025

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.6K

有效的算法用于构建具有代表性的匹配对,具有增强的概括性.

Bo Zhang1

  • 1Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.

Biometrics
|August 3, 2023
PubMed
概括
此摘要是机器生成的。

本研究引入了一个网络流统计匹配算法,以将观测数据与目标人群对齐,改进现实世界证据 (RWE) 分析. 该方法有助于调和观察性研究和随机对照试验 (RCT) 之间的差异.

关键词:
在 RCT DUPLICATE 倡议中,妇女健康倡议妇女健康倡议可以概括的概括性.统计匹配的统计匹配.试验模拟的试验模拟

更多相关视频

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
08:12

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

Published on: March 1, 2022

2.6K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.6K

相关实验视频

Last Updated: Jul 20, 2025

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

7.6K
A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments
08:12

A Psychophysics Paradigm for the Collection and Analysis of Similarity Judgments

Published on: March 1, 2022

2.6K
A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.6K

科学领域:

  • 生物统计学 生物统计学
  • 流行病学 流行病学
  • 医疗信息学 医疗信息学

背景情况:

  • 来自观察性研究的真实世界证据 (RWE) 越来越多地被使用,但往往显示出与随机对照试验 (RCT) 的差异.
  • 调和不同数据源之间的发现 (例如,观测与RCT,或不同的观测数据库) 需要解决人口差异.
  • 该RCT DUPLICATE倡议强调需要方法来比较RWE与RCT.

研究的目的:

  • 开发和展示一个高效的,基于网络流的统计匹配算法.
  • 从观测数据中创建匹配的对,以模拟目标人口的共变量分布.
  • 证明该算法在调和观察研究和RCT之间的差异方面的实用性.

主要方法:

  • 开发了一种基于网络流的新型统计匹配算法.
  • 该算法从观测数据中生成匹配的对,以反映目标人口的共变量分布.
  • 该方法用于分析来自妇女健康倡议 (WHI) 的激素替代疗法 (HRT) 数据.

主要成果:

  • 统计匹配算法成功创建了可比的研究群体.
  • 在调整心血管风险后,在WHI试验和观察性研究之间,激素替代疗法的心脏保护作用的差异仍然存在.
  • 当进一步调整HRT开始年龄和之前使用雌激素加孕激素时,差异减少了.

结论:

  • 拟议的网络流匹配算法有效地将来自不同数据源的群体对齐.
  • 该方法有助于协调现实证据和随机对照试验结果之间的不一致性.
  • 该算法可在R包match2C中提供,以获得更广泛的应用.