功能性MRI技术表明,压力系统与三个大规模核心大脑网络相互作用,以帮助协调适应性反应:系统性审查
George Paltoglou1,2,3, Charikleia Stefanaki1,3, George P Chrousos1,3
1University Research Institute of Maternal and Child Health and Precision Medicine, Medical School, National and Kapodistrian University of Athens, "Aghia Sophia" Children's Hospital, Athens 11527, Greece.
Current neuropharmacology
|August 3, 2023
概括
急性压力会影响大脑网络,改变突出 (SN),默认模式 (DMN) 和中央执行 (CEN) 网络连接. 这些动态的功能连接变化是适应性的,有助于生存决策.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 心理生理学 心理生理学
背景情况:
- 人类的压力系统 (SS) 在生存和决策方面发挥着至关重要的作用.
- 了解压力反应的神经支包括检查关键的大脑网络.
- 功能磁共振成像 (fMRI) 和功能连接 (FC) 分析是研究大脑功能的强大工具.
研究的目的:
- 综合fMRI和FC关于人类压力系统 (SS) 功能的数据.
- 在压力期间调查突出网络 (SN),默认模式网络 (DMN) 和中央执行网络 (CEN) 的动态相互作用.
- 阐明急性压力如何调节神经网络活动和连接.
主要方法:
- 在主要科学数据库 (Medline,Scopus,Clinical Trials.gov,Google Scholar) 的系统文献搜索.
- 包括28篇全文文章进行定性综合.
- 分析的重点是2022年9月之前发表的研究.
主要成果:
- 与静止状态相比,急性压力显著改变了SN,DMN和CEN中的网络内部和网络间的功能连接 (FC) 和活动.
- SS激活与SN活动正相关,与DMN活动负相关,对CEN活动产生双相影响.
- 网络之间的FC转换涉及DMN-CEN连接的增加和SN-CEN连接的减少,促进执行职能和任务参与.
结论:
- 压力系统的激活与突出网络 (SN) 功能密切相关.
- 压力激素调节网络FC,增强SN,减弱DMN,并双相影响CEN活动.
- 这些适应性神经变化优化了压力下的决策和生存反应.
关键词:
压力系统 压力系统中央执行网络的中央执行网络.默认模式网络模式 默认模式网络模式功能性核磁共振成像 (MRI) 的使用.功能连接性的功能连接性正念. 保持正念. 保持正念.突出网络突出网络突出网络更多相关视频
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