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怀孕时肝细胞癌:一个系统的审查

Francesco Marasciulo¹, Irene Passerini¹, Anna Fichera¹

¹Division of Obstetrics and Gynecology, ASST Spedali Civili, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.

Acta obstetricia et gynecologica Scandinavica

|August 3, 2023

概括

妊娠期间的肝细胞癌 (HCC) 对母亲和新生儿构成高风险. 无症状妇女的早期诊断或通过异常的α-fetoprotein (AFP) 查改善了母亲的结果.

科学领域:

在瘤学瘤学.
肝病学肝病学是一种肝病学.
孕产妇和胎儿医学孕产妇和胎儿医学

背景情况:

肝细胞癌 (HCC) 是一种主要的肝癌,通常与慢性肝病有关.
怀孕可以使HCC诊断和治疗复杂化,原因是阿尔法-胎蛋白 (AFP) 水平升高.
现有的诊断工具,如超声波,CT和MRI用于HCC检测.

研究的目的:

系统地审查怀孕期间HCC的临床特征.
描述与怀孕期间诊断的HCC.相关的孕妇和新生儿结局.

主要方法:

对怀孕期间或产后诊断的HCC病例报告和病例系列的系统审查 (症状在怀孕期间出现).
从创立到2023年3月的文献搜索.
该协议已注册在PROSPERO (ID CRD42021275584) 的账户中.

主要成果:

分析了63例患有HCC的怀孕,其中B型肝炎病毒感染 (47%) 和肝硬化 (22%) 是常见的易感因素.
超声波是主要的检测方法;在61%的测试患者中发现了升高的AFP.
孕产妇死亡率高 (42%在6个月内),无症状妇女的存活率更高 (29%>24个月). 28天的新生儿存活率为61%.

结论:

怀孕相关的HCC带来了显著的孕产妇和新生儿死亡风险.
在无症状,高风险个体或通过异常的AFP查的早期诊断与改善的孕产妇结果有关.

关键词:

肝硬化是肝硬化的一种疾病.乙型肝炎病毒感染乙型肝炎病毒感染肝细胞癌是肝细胞癌.怀孕怀孕怀孕怀孕怀孕这是一种α-fetoprotein.

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