大脑粉样蛋白沉积预测出血小血管疾病的长期认知衰退
Ya-Chin Tsai1, Hsin-Hsi Tsai2,3, Chia-Ju Liu4
1Department of Nuclear Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan.
Brain and behavior
|August 3, 2023
概括
大脑粉样蛋白沉积与小血管疾病 (SVD) 和脑内出血 (ICH) 幸存者患者的长期认知能力下降有关. 粉样蛋白阳性个体面临着明显更高的痴呆和认知衰退的风险.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 老年病的医生 老年病的医生
背景情况:
- 出血小血管疾病 (SVD) 和脑内出血 (ICH) 的幸存者面临长期的认知挑战.
- 大脑粉样蛋白沉积是神经退行性疾病的关键病理特征.
- 粉样蛋白负担和ICH后的认知轨迹之间的关系尚未完全理解.
研究的目的:
- 研究大脑粉样蛋白沉积与长期认知结果之间的关联.
- 为了确定粉样蛋白阳性是否预测SVD的ICH幸存者的认知能力下降.
- 探索粉样蛋白在ICH后认知障碍进展中的作用.
主要方法:
- 预期招募68名没有痴呆症的ICH患者.
- 基线大脑MRI和匹兹堡化合物B (PiB) 定子发射断层扫描 (PET).
- 认知评估 (MMSE,CDR) 和多变量考克斯回归分析,平均随访时间为3.8年.
主要成果:
- 粉样蛋白阳性 (PiB(+)) 患者年龄较大,患脑粉样蛋白血管病变 (CAA) 的可能性更高.
- PiB(+) 与更高的痴呆转化风险 (HR=15.7) 和MMSE下降 (HR=6.2) 有显著的关联.
- 粉样蛋白阳性仍然是痴呆症和认知衰退的独立预测因子,即使在调整混因子后.
结论:
- 大脑粉样蛋白沉积是与SVD相关的ICH的长期认知衰退的重要贡献者.
- 粉样蛋白成像可以识别患有ICH后渐进性认知障碍风险较高的个体.
- 进一步的研究是有必要的,以探索向粉样蛋白在这个人群中的治疗策略.
相关概念视频
01:26Alzheimer's Disease: Overview
522
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
522
01:30Dementia
139
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
139
03:03Amyloid Fibrils
9.6K
Amyloid fibrils are aggregates of misfolded proteins. Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils.
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
9.6K