患者报告症状的模式和与社会人口统计学和全身性硬化症疾病特征的关联:一个硬化皮肤病患者中心干预网络 (SPIN) 队列横截面研究
Robyn K Wojeck1, Mitchell R Knisely2, Donald E Bailey2
1University of Rhode Island, Kingston, Rhode Island, USA.
EClinicalMedicine
|August 3, 2023
概括
系统性硬化症患者可以按症状水平分组,其中一组尽管有高的身体症状,但表现出较低的心理健康症状. 需要进一步的研究来了解性和改善应对策略.
科学领域:
- 类风湿病学 类风湿病学
- 患者报告的结果
- 症状集群分析 症状集群分析
背景情况:
- 系统性硬化症是一种复杂的疾病,患者报告的症状模式不明.
- 识别症状集群对于个性化的患者护理和管理至关重要.
研究的目的:
- 根据焦虑,抑郁,疲劳,睡眠障碍和疼痛来确定系统性硬化症患者的不同类别.
- 检查与这些症状集群相关的社会人口结构和疾病相关因素.
主要方法:
- 利用了来自2212名脊髓灰质炎患者中心干预网络队列参与者的基线数据 (2014-2020年).
- 在 PROMIS-29 v2.0 数据上使用隐性配置分析来定义症状集群.
- 在确定的患者类别中比较社会人口统计和疾病特征.
主要成果:
- 确定了五个不同的患者类别:四个基于症状严重程度 (低至非常高) 和一个高疲劳/睡眠/疼痛但低焦虑/抑郁.
- 在症状类和社会人口统计因素 (年龄,教育,种族,婚姻状况) 和疾病严重程度 (扩散性疾病,肌摩擦擦,关节收缩,胃肠道症状) 之间发现了显著的关联.
- "高疲劳/睡眠/疼痛和低焦虑/抑郁症"组与"高"严重性类的疾病严重程度和社会人口统计特征相同.
结论:
- 大多数系统性硬化症患者可以根据与人口和疾病变量相关的一致症状水平进行分类.
- 一个值得注意的例外是,一个身体症状很高但精神健康症状很低的群体,这表明潜在的弹性.
- 建议进行进一步的研究,以探索弹性机制和有效的应对策略,以提高系统性硬化症患者的生活质量.
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