帕金森病与静止性低血压中的言语记忆功能受损的延迟回忆机制:多重成像研究
Xiaofan Xue1,2, Anqi Huang2, Jingrong Zeng2
1Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Frontiers in neurology
|August 3, 2023
概括
帕金森病患者的正静性低血压 (OH) 呈现出较差的口头记忆回忆. 这种认知缺陷可能源于大脑动态自我调节 (dCA) 受损,影响中叶代谢.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 医疗成像医学成像
背景情况:
- 静止性低血压 (OH) 与帕金森病 (PD) 中的自主功能障碍和认知障碍有关.
- 具体的认知功能与PD中的OH之间的确切关系尚不清楚.
研究的目的:
- 为了研究PD患者的认知领域表现,有和没有OH.
- 评估神经成像和动态大脑自我调节 (dCA) 参数,与PD中OH状态相关.
主要方法:
- 31名PD患者 (20名有OH,11名没有) 接受了血压监测,认知测试,dCA测量,MRI和18F-FDG PET/CT.
- 节奏性血压记录和活动站立测试评估了神经性OH.
主要成果:
- 患有OH的PD患者与没有OH的患者相比,表现出明显较差的延迟口语回忆 (p=0.042).
- 在dCA期间观察到右极低频 (VLF) 增益的显著差异 (p=0.045) 和右中间叶与叶之间的SUV比率 (p=0.049).
- 延迟回忆记忆与右侧VLF增长有负相关性,与中间叶与叶SUV比率有正相关性.
结论:
- 患有OH的PD患者经历了减弱的延迟口头回忆记忆.
- 损坏的dCA可能会导致中间叶的代谢功能障碍,导致患有OH的PD的记忆缺陷.
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