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针对初级失眠患者大脑的影响:基于fMRI研究的坐标元分析
Shuhan Zang1, Ying Chen1, Haonan Chen1
1The First School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing, China.
Frontiers in neurology
|August 3, 2023
概括
针在患有初级失眠 (PI) 的患者中有效调节大脑活动,特别是在额叶和前部. 这一系统性审查突出了针的重点.
科学领域:
- 神经科学是一个神经科学.
- 综合医学是一个整体的医学.
- 睡眠医学 睡眠医学
背景情况:
- 初级失眠 (PI) 是一种普遍存在的全球疾病,需要有效的治疗,副作用最小.
- 针,一种传统的中医技术,越来越多地被认为是PI治疗,一些证据表明它对睡眠参数和大脑活动的影响.
- 由于个人研究的局限性,需要对PI中针的神经生物学影响进行系统审查.
研究的目的:
- 系统地审查和进行基于坐标的功能磁共振成像 (fMRI) 研究的元分析,评估PI患者的针治疗.
- 阐明针治疗初级失眠的治疗效果的核心神经机制.
主要方法:
- 在多个数据库 (Web of Science,PubMed,Embase等) 进行了全面的文献搜索. 从开始到2022年12月.
- 包括11项涉及305名PI患者和116名健康对照者的研究.
- 基于种子的D绘图与对象图像的变换 (SDM-PSI) 用于元分析,以确定PI中的针治疗影响的大脑区域.
主要成果:
- 患有PI的患者在左上额头,右角和小脑中表现出改变的区域均性和低频波动.
- 针治疗显著改善了右上额头回环,左下额头回环,左下状回环,左上边缘回环,双边前,左补充运动区域和右副海马回环的脑功能.
- 非针针主要影响前额叶区域.
结论:
- 针显著影响PI患者的默认模式网络,显著影响额叶和前.
- 非针针也可能为前脑区域带来好处.
- 这些发现支持针作为一种潜在的治疗干预,通过调节特定的神经通路来治疗初级失眠.
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