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拉西-L检测早期的认知变化在前运动表现亨廷顿病:一个复制和验证研究

Luis A Sierra¹, Shelby B Hughes^2,3, Clementina J Ullman¹

¹Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States.

Frontiers in neurology

|August 3, 2023

概括

语义干扰和学习 (LASSI-L) 的洛文斯坦-阿塞维多尺度有效地检测了亨廷顿病前 (preHD) 的早期认知衰退. 这种口头学习任务显示出高灵敏度和可靠性,在识别微妙的认知变化方面表现优于其他测试.

科学领域:

神经科学是一个神经科学.
认知心理学认知心理学

背景情况:

认知能力下降,包括执行功能,处理速度和记忆缺陷,是亨廷顿前运动性疾病 (preHD) 的早期指标.
以前建议使用Loewenstein-Acevedo语义干扰和学习量表 (LASSI-L) 来捕捉这些在HD前的早期认知变化.

研究的目的:

复制和验证LASSI-L在使用更大的数据集检测preHD认知衰退中的实用性.
进一步分析LASSI-L的性能,并将其与已建立的认知评估进行比较.

主要方法:

对50名参与者 (25名preHD,25名对照) 进行了LASSI-L,并与MMSE,Trail A & B,SCWT,SDMT,Semantic Fluency和CVLT-II进行了性能比较.
在12个月的时间间隔内研究了接收器运行曲线 (ROC) 和实践效应.
在预测远离诊断的preHD子组 (远部子组) 的比较表现,基于CAPs得分和通过与皮层下缩指标的相关性评估构造有效性.

主要成果:

与对照组相比,PreHD参与者在所有LASSI-L截面上显示出显著的差异.
主动语义干扰 (PSI) 部分表现出高灵敏度 (d=1.548),可靠性 (rho=0.88),以及ROC曲线下的优秀区域 (AUROC=0.855).
在HD前的Far子组中,PSI是FDR校正后仍然显著的唯一认知评估 (p=0.03),PSI的入侵与尾状体积负相关.

结论:

LASSI-L是一个敏感,可靠和高效的工具,用于识别HD前的认知衰退.
LASSI-L的独特范式,针对多个认知领域,超过了许多已建立的测试在检测早期损害.
进一步的纵向验证可以将LASSI-L确定为HD前临床研究的有价值生物标志物.

关键词:

亨廷顿病是亨廷顿病的一种疾病.在LASSI-L的过程中,有关认知性的认知.执行职能执行职能是指执行职能.预发动机显示 HD 高清显示语义干扰是一种语义干扰.

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