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在喀土穆州的COVID-19患者中对血清补充C4的评估:基于病例控制的研究

Mohammed Yahya¹, Yousif Ali Rahamtalla¹, Nasr Mohammed Nasr²

¹Department of Microbiology, Sudan University of Science and Technology, Khartoum, Khartoum, Sudan.

|August 3, 2023

概括

COVID-19患者的血清补充C4水平高于健康人群. 与非严重病例相比,严重的COVID-19病例的补充C4度较低,这表明补充级联参与.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
生物化学生物化学

背景情况:

补体系统对于天生的免疫力和炎症至关重要,防御病原体.
补充蛋白,如C4,在免疫反应中起作用.
了解病毒感染中的补体系统变化至关重要.

研究的目的:

为了评估Khartoum的COVID-19患者的血清补充C4度.
为了比较COVID-19患者和健康对照者之间的C4水平.
调查C4水平与COVID-19严重程度 (ICU与非ICU) 和年龄相关.

主要方法:

分析了100名参与者的血清样本 (50名COVID-19病例,50名健康对照).
补充C4度以每分升毫克 (mg/dL) 的单位测量.
数据使用SPSS版本20进行分析,包括t测试和ANOVA.

主要成果:

与对照组 (23.90 ±10.229 mg/dL) 相比,COVID-19患者的C4平均水平 (37.44 ±18.618 mg/dL) 显著更高 (p≤0.01).
严重的病例 (ICU) 的C4水平平均较低 (25.00±17.85毫克/毫升),而不是严重的病例 (43.85±15.712毫克/毫升) (p≤0.01).
不同年龄组之间没有观察到C4水平的显著差异 (P = 0.735).

结论:

在COVID-19患者中血清C4升高表明疾病期间补充级联激活.
在严重的COVID-19患者中,较低的C4水平可能表明补充剂消耗或失调.
补充C4水平可以作为COVID-19严重程度的潜在生物标志物.

关键词:

补充C4 补充C4 补充这就是Covid-19的原因.苏丹的苏丹人

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