多种微量元素与全因死亡风险之间的剂量反应关系:一项前性队列研究
Shaohua Zhao1,2, Shaohua Wang3, Xiaorong Yang4,5
1Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China.
Frontiers in nutrition
|August 3, 2023
概括
这项研究发现,血液中的,和含量,以及微量元素的混合物,与全因死亡风险有关. 监测这些因素对于公共卫生至关重要.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 微量元素是必不可少的微量营养素,但在较高度下可能有毒.
- 了解微量元素暴露和死亡率之间的关系对于公共卫生至关重要.
- 之前的研究已经探讨了个别的微量元素,但人们对综合效应的理解较少.
研究的目的:
- 为了前性地研究各种微量元素对所有原因死亡率的独立和联合影响.
- 分析血液,血清和尿液中的微量元素度与死亡风险的关系.
- 识别与增加或减少死亡率相关的特定微量元素及其混合物.
主要方法:
- 利用了来自国家健康和营养检查调查的5412人的数据.
- 采用了考克斯的比例危险模型,受限立方线模型和贝叶斯核机器回归 (BKMR) 模型.
- 分析血液 (,),血清 (铜,) 和尿液 (,,,,,) 的度.
主要成果:
- 在70个月的中位数随访期间,发生了356例死亡.
- 较高的和水平与较低的死亡率相关 (HRs:0.47).
- 较高的含量与死亡率的增加有关 (HR: 1.57).
- 对于和,观察到非线性关联.
- 鉴定出微量元素混合物对死亡率的显著影响,特别是在较低的暴露水平下.
结论:
- 多种微量元素及其混合物与全因死亡率有关.
- 医疗保健提供者和公共卫生机构应加强对微量元素的监测和管理.
- 需要进一步的研究,包括人口研究和动物实验,以阐明潜在的机制.
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