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最近在使用基于质谱的技术检测动物来源的食物兴奋剂方面取得了进展

Qiang Zhang¹, Hongying Du², Yingjian Zhang³

¹Graduate School, Capital University of Physical Education and Sports, Beijing, China.

Frontiers in nutrition

|August 3, 2023

概括

质谱学 (MS) 提高了在食品中检测动物衍生的兴奋剂的性能. 先进的MS技术为动物产品中发现兴奋剂提供了更高的灵敏度和效率.

科学领域:

食品安全和分析化学
兽医药物分析兽医药物分析
法医科学法医科学

背景情况:

越来越多的动物衍生的兴奋剂在食品中的滥用.
对滥用物质可靠检测方法的需求日益增长.
需要对质谱仪 (MS) 进行系统评估,以检测动物衍生的兴奋剂.

研究的目的:

审查染色体质谱法 (CMS) 的应用,用于选和检测动物来源的食物刺激剂.
分析常见的合成类固醇,β受体激动剂,泽拉醇和葡萄皮质激素的动物来源.
探索CMS在检测和分析动物来源食品方面的潜力.

主要方法:

在Web of Science和谷歌学者数据库中的系统文献搜索 (至2023年4月).
收录标准:在过去5年的出版物,英语,以及食品分析,环境化学或聚合物科学的研究领域.
使用的关键词: "质谱", "类固醇类固醇", "β-2激动剂", "糖皮质激素", "zearalenone" 和 "兴奋剂".

主要成果:

传统方法 (薄层染色学,ELISA) 的检测极限很高.
气色谱-质谱法 (GC-MS) 和液色谱-并联质谱法 (LC-MS/MS) 广泛使用,但需要更灵敏,可重复的方法,分析时间更快.
先进的MS技术 (HRMS,UHPLC-MS/MS,GC-C-IRMS,UHPLC-HRMS,2D染色学) 在微量非法药物检测方面提供了显著的优势.
由于稳定性和成本效益,新型采样方法 (干血/尿液斑点,体积吸收微采样) 越来越受欢迎.

结论:

质谱显著提高了检测动物产品中的兴奋剂的效率.
预计MS技术的不断进步将扩大其在兴奋剂检测和分析中的应用.
进一步开发敏感,高通量分析方法对于确保食品安全和完整性至关重要.

关键词:

动物来源的食品来源于动物.染色学-质谱学-质谱学葡萄糖皮质类药物是什么合成类固醇是一种合成类固醇.泽拉伦诺洛尔 (Zearalenol) 是一种这种药物是β-agonists.

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