无水性状汗腺的转录组分析显示,状汗腺上的嗅觉受体以依赖质的方式调节汗流
Naoya Murayama1, Takafumi Miyaki1, Daisuke Okuzaki2
1Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
状汗腺中的嗅觉受体在男性和女性中不同调节出汗. 这一发现可能会通过将气味分子准这些受体来治疗出汗障碍的新疗法.
科学领域:
- 生理学 生理学 生理学
- 内分泌学 在内分泌学.
- 皮肤病学 皮肤病学
背景情况:
- 汗水对于维持人体平衡至关重要,但汗水障碍缺乏有效的治疗方法.
- 了解排汗的调节是开发治疗无水和其他出汗疾病的关键.
研究的目的:
- 为了研究调节神经汗腺功能的分子机制.
- 为了确定潜在的治疗汗障碍的目标.
主要方法:
- 对水性和无水性状汗腺进行比较的转录组分析.
- 在现场杂交和免疫组织化学,以确认嗅觉受体表达.
- G-蛋白激活测定和定量上运动轴突反射试验,以评估β-离子子子的作用.
主要成果:
- 鉴定了无水性与水性汗腺中嗅觉受体 (OR) 的差异表达.
- 嗅觉受体OR51A7和OR51E2已在人类的状汗腺中得到证实.
- 通过OR51A7/OR51E2,β-ionone激活了G蛋白,并在性别之间不同地调节出汗,在女性中减弱,在男性中增加出汗.
结论:
- 嗅觉受体表达在状汗腺可以调节出汗,以响应气味,与性别特异性影响.
- 这些发现表明嗅觉受体是治疗出汗障碍的新目标.
更多相关视频
09:53Real-time In Vitro Monitoring of Odorant Receptor Activation by an Odorant in the Vapor Phase
Published on: April 23, 2019
10:16Perforated Patch-clamp Recording of Mouse Olfactory Sensory Neurons in Intact Neuroepithelium: Functional Analysis of Neurons Expressing an Identified Odorant Receptor
Published on: July 13, 2015
相关概念视频
Accessory Structures of the Skin: Sweat Glands
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
Physiology of Smell and Olfactory Pathway
The olfactory...
Olfaction
The olfactory receptors are embedded in the cilia of the...
Olfactory Receptors: Location and Structure
Regulation of Transpiration by Stomata
Introduction to the Integumentary System
The skin, which is the primary organ of the integumentary system, consists of three main layers: the epidermis, dermis, and hypodermis (subcutaneous tissue). The epidermis is the...
