HER2-低患者与 HER2-零患者之间的治疗结果的差异,激素受体阳性晚期乳腺癌接受Ribociclib治疗
Baha' Sharaf1, Hala Abu-Fares1, Faris Tamimi1
1Department of Internal Medicine, King Hussein Cancer Center, Amman, Jordan.
Breast cancer (Dove Medical Press)
|August 3, 2023
概括
患有HER2-零转移性乳腺癌 (MBC) 的患者在内分泌疗法 (ET) 和利博西基利比患有HER2-低疾病的患者表现更好. 这表明HER2表达水平会影响MBC治疗的有效性.
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
- 乳腺癌治疗方法 乳腺癌治疗方法
背景情况:
- 缺少人体表皮生长因子受体-2 (HER2) 表达的转移性乳腺癌 (MBC) 现在被分类为HER2-零 (IHC分数为0) 和HER2-低 (IHC1-2+与负ISH).
- 了解这些HER2-阴性亚型之间的治疗差异对于优化患者护理至关重要.
研究的目的:
- 为了研究和比较治疗结果在HER2-零与HER2-低转移性乳腺癌患者接受内分泌疗法 (ET) 结合CDK4/6抑制剂 ribociclib.
- 确定HER2表达水平是否会影响HR-阳性/HER2-阴性MBC中ET和ribociclib的疗效.
主要方法:
- 从HR-阳性/HER2-阴性MBC患者的回顾性数据收集,这些患者接受了ribociclib和一种芳酶抑制剂 (AI) 或富尔韦斯特兰特治疗.
- 为了进行比较分析,患者被分为HER2-零 (IHC 0) 和HER2-低 (IHC 1-2+,ISH负) 组.
主要成果:
- 总共分析了257名患者,114人 (44.4%) 患有HER2-零,143人 (55.6%) 患有HER2-低疾病.
- 总体响应率 (ORR) 在HER2-零组 (52.0%) 与HER2-低组 (39.4%) (p=0.005) 相比显著更高.
- 在HER2-零患者中,中位数无进展生存时间 (PFS) 较长 (22.2个月),而在HER2-低患者中 (17.3个月) (P=0.0039). 低HER2状态是劣质PFS的独立预测因素.
结论:
- 在HER2-阴性MBC中HER2表达水平可能会影响治疗结果,当治疗ET和ribociclib时.
- 与HER2-低疾病患者相比,患有HER2-零疾病的患者表现出更高的响应率和PFS.
- 这些发现可能有助于为患有低HER2转移性乳腺癌的患者选择适当的治疗策略,等待在更大的研究中得到确认.
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