电疗法用于治疗因痴呆症引起的激动和相关行为障碍患者:系统性审查
Florindo Stella1,2, Márcia Radanovic1, José Gallucci-Neto3
1Universidade de São Paulo, Faculdade de Medicina, Instituto de Psiquiatria, LIM-27, São Paulo SP, Brazil.
Dementia & neuropsychologia
|August 3, 2023
概括
电疗法 (ECT) 显示出治疗痴呆症患者在药物失效时严重动荡的前景. 虽然有效和安全,但审查强调缺乏高水平的随机对照试验.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 在痴呆症患者中,行为障碍很常见.
- 对这些症状的药理疗法有效性有限.
- 电疗法 (ECT) 对精神疾病有效,并可能有助于痴呆症的严重动荡.
研究的目的:
- 审查关于ECT治疗痴呆症患者激动症治疗的疗效,安全性和耐受性的出版物.
- 评估当前在这个患者群体中对ECT的证据基础.
主要方法:
- 一个系统的分析关于ECT的出版物对于痴呆症的严重动荡.
- 根据研究设计根据证据水平对文章的分类.
- 包括19项涉及156名患者的研究.
主要成果:
- 审查发现缺乏随机化,假控制的临床试验 (证据水平1).
- 包括的研究包括一个病例控制,一个开放标签,三个追溯分析和14个病例系列/报告.
- 患者经历了短期的副作用,如 postictal delirium 和心血管变化.
结论:
- 在患有痴呆症的患者中,ECT显著改善了激动.
- 尽管有方法上的局限和已知的副作用,但ECT被认为是治疗痴呆症严重动荡的安全有效的治疗方法.
- 需要进一步进行高质量的研究,特别是随机对照试验,以巩固这些发现.
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