中小肠片段的易斯评分可能预测休眠克罗恩病患者的长期结果
Offir Ukashi1, Doron Yablecovitch2, Adi Lahat2
1Gastroenterology Institute and Internal Medicine Department A, Sheba Medical Center, Tel HaShomer, Ha'ela 1, Ramat Gan 52621, Israel.
Therapeutic advances in gastroenterology
|August 3, 2023
概括
视频囊内镜视频囊内镜
科学领域:
- 胃肠病学和肝病学
- 炎症性肠道疾病研究研究
- 诊断成像技术 诊断成像技术
背景情况:
- 视频囊内镜 (VCE) 建立用于诊断小肠炎症和预测静止克罗恩病 (CD) 中的爆发.
- 关于VCE在CD患者的预测作用的扩展后续数据有限.
研究的目的:
- 为了预测克罗恩病患者的临床恶化,患者患有静止疾病.
- 评估易斯评分在识别长时间 (>24个月) 随访期内面临未来恶化风险的患者中的有用性.
主要方法:
- 从前性研究 (2013-2018) 中对静止小肠CD的成年患者进行后期分析.
- 分析了扩展的临床数据 (至2022年4月),包括VCE,炎症生物标志物和磁共振肠道学.
- 临床恶化被定义为包括手术,住院或治疗变化在内的综合结果.
主要成果:
- 在基线时,中小肠段易斯评分 (midLS) ≥135预测了未来的临床恶化 (AUC 0.767,HR 6.317,NPV 93%).
- 复杂和严格的疾病表型与更高的恶化风险有关.
- 在敏感性分析中,中期LS显示出独立于疾病表型的预测值.
结论:
- 中小肠段的易斯评分 (midLS) 有效地预测了休眠克罗恩病患者的治疗失败,在中位数为5年的随访期间.
- 在CD管理中, midLS作为一种有价值的风险分层工具,无论疾病的表型如何.
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