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诺莫格拉姆预测模型称为"ADPLCP",用于预测老年人中与线化物相关的血小板缺血症

Yanxin Liu¹, Jiang Wang², Tingting Liu¹

¹Department of Pulmonary and Critical Care Medicine, The Second Medical Center, National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing 100853, China.

Journal of intensive medicine

|August 3, 2023

概括

一个新的风险评分,ADPLCP,有助于预测老年患者的线化物相关血小板缩 (LAT). 这种工具有助于早期发现和干预LAT,改善患者的治疗结果.

科学领域:

药理学药理学是指药理学的学科.
老年病的医生老年病的医生
血液学血液学血液学

背景情况:

莱涅佐利德相关的血小板缺血 (LAT) 是一种严重的不良事件,需要停止药物治疗,并且与预后不佳有关.
之前对LAT风险因素的研究样本规模小,对老年人的数据有限.
在老年人中缺乏简单的,早期预测性LAT风险评分,阻碍了及时干预.

研究的目的:

为了确定与linezolid治疗的老年患者中LAT的风险因素.
开发和验证一个基于nomogram的风险预测模型来预测该群体中LAT的风险.
建立一个实用的工具,用于早期识别和管理LAT.

主要方法:

一个单一中心的回顾性病例控制研究,涉及428名用linezolid治疗的老年患者.
收集人口统计数据和基线实验室发现.
后勤回归分析以建立ADPLCP (年龄,持续时间,血小板,白细胞,肌素清除量,蛋白质) 诺米克风险预测模型.

主要成果:

在研究的老年人群中,LAT的发病率为35.5%.
对LAT显著的危险因素包括年龄较大 (≥80岁),线索利德持续时间较长 (≥10天),基线血小板计数较低,基线白细胞计数较高,肌素清除率降低 (<50毫升/分钟),总蛋白质较低 (<60克/升).
ADPLCP名录表显示出良好的预测性能 (AUC=0.802),并允许将风险分为低,中,高等类别.

结论:

ADPLCP风险评分尺度已成功开发,用于预测老年患者的LAT.
ADPLCP是一个简单而可行的工具,用于早期LAT预测.
这种风险评分可以指导LAT早期药物戒断或干预策略.

关键词:

年长的个人老年人.与林氏素相关的血小板缺血症.这个名字叫做Nomogram.风险预测模型的风险预测模型.

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