介酶干细胞和结缔组织疾病:从长椅到床边
Yue Shi1, Nan Jiang1, Mengtao Li1
1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology; State Key Laboratory of Complex Severe and Rare Diseases; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing 100730, China.
Journal of translational internal medicine
|August 3, 2023
概括
介质细胞干细胞 (MSCs) 通过调节免疫力来治疗结合组织疾病 (CTDs) 的前景有望. 临床研究表明有好处,但需要进一步的研究,以在CTD中获得最佳的MSC治疗.
科学领域:
- 免疫学 免疫学 免疫学
- 再生医学是一种再生医学.
- 类风湿病学 类风湿病学
背景情况:
- 连接组织疾病 (CTD) 涉及复杂的免疫失调.
- 介酶干细胞 (MSCs) 具有免疫调节的特性.
- MSCs为像CTDs这样的免疫媒介疾病提供了潜在的治疗策略.
研究的目的:
- 审查MSCs的免疫调节机制.
- 总结基于MSC的CTD治疗方法的临床前和临床证据.
- 确定在CTD中MSC治疗的挑战和未来研究方向.
主要方法:
- 在CTD动物模型中进行的临床前研究的审查.
- 在CTD患者中分析临床试验数据 (试点,队列,RCT).
- 对系统性红斑狼 (SLE),类风湿性关节炎 (RA),系统性硬化症 (SSc),原发性肖格伦综合征 (pSS) 和异常性炎症性肌肉病 (IIM) 的MSC研究的审查.
主要成果:
- 在CTD动物模型中,MSC显示症状和组织学改善.
- 试点研究和RCT显示,MSC治疗在重症,耐药性SLE,RA和SSc中具有前景.
- 在pSS和IIM的早期研究也显示出令人鼓舞的结果.
- 效率因MSC输送路线,时间,来源和剂量而异.
结论:
- MSCs是CTD的一个有前途的免疫调节疗法.
- 需要进一步的研究来优化MSC治疗参数和药物组合.
- 细胞工程方法可以增强MSC对CTD的治疗应用.
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