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相关概念视频

Complement System01:27

Complement System

2.4K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Antimicrobial Proteins01:23

Antimicrobial Proteins

1.0K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
1.0K
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.4K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.4K
Cerebrospinal Fluid01:21

Cerebrospinal Fluid

2.4K
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
2.4K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

52
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
52
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

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The pathophysiology of pneumonia involves the following steps:
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相关实验视频

Updated: Jul 20, 2025

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
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A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

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COVID,补充,以及大脑的大脑.

Sonia I Vlaicu1,2, Alexandru Tatomir1, Jacob Cuevas1

  • 1Department of Neurology, University of Maryland, School of Medicine, Baltimore, MD, United States.

Frontiers in immunology
|August 3, 2023
PubMed
概括
此摘要是机器生成的。

在长期COVID中,SARS-CoV-2病毒会影响大脑,导致神经炎症和认知能力下降. 这篇评论强调了微质反应,神经发生障碍和血脑屏障损伤,这涉及COVID-19神经后续的补充路径.

关键词:
在C5b-9中使用.在这里,我们可以看到COVID COVID COVID.大脑大脑大脑的大脑大脑认知功能障碍 认知功能障碍互补系统是互补的系统.内皮细胞是内皮细胞.

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High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain
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相关实验视频

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High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

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A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain
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科学领域:

  • 神经学 神经学
  • 免疫学 免疫学 免疫学
  • 病毒学 病毒学

背景情况:

  • COVID-19 (由SARS-CoV-2引起) 与神经系统并发症有关,包括认知功能障碍 (长期COVID).
  • 神经炎症及其对大脑功能的影响是研究的主要领域.
  • 了解这些机制对于管理长期COVID症状至关重要.

研究的目的:

  • 审查了解神经炎症在COVID-19大脑病理学中的作用的最新进展.
  • 要总结SARS-CoV-2感染的神经后果.
  • 探索补充路径在COVID-19相关的大脑损伤中的参与.

主要方法:

  • 关于SARS-CoV-2对人类和老鼠大脑的影响现有研究的综述.
  • 在COVID-19患者中分析神经成像 (MRI) 发现.
  • 对死后脑组织进行检查,以检测病毒存在,免疫细胞反应和补体沉积.

主要成果:

  • SARS-CoV-2 感染与微质反应性,神经发生减少,寡细胞损失和髓损伤有关.
  • COVID-19患者的灰质厚度和大脑大小降低,与认知能力下降相关.
  • 在COVID-19大脑中,血脑屏障泄漏,纤维素扩散和补充通路激活 (经典和替代) 的证据.

结论:

  • SARS-CoV-2 直接影响大脑内皮细胞,可能导致血栓和中风.
  • 神经炎症和补充系统激活 (C3b,MAC) 在COVID-19的神经后果中起着重要作用.
  • 这些免疫媒介过程有助于在COVID-19患者中观察到的各种神经症状.