通过转基因组学揭示的分剂肠道制剂儿童的肠道微生物群
Yu Zou1, Sihui Zeng1, Moxian Chen2
1Division of Gastroenterology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.
Frontiers in cellular and infection microbiology
|August 3, 2023
概括
分剂量聚乙烯甘醇 (PEG) 肠道制备剂用于结肠镜检查暂时改变儿科肠道微生物群的组成和功能. 肠道微生物群的多样性和功能在手术后两周内恢复,证明了弹性.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 儿科 儿科 儿科
背景情况:
- 分剂量聚乙烯甘醇 (PEG) 是结肠镜准备的标准.
- 了解它对儿科肠道微生物群的影响至关重要.
研究的目的:
- 在分剂量PEG肠道制备后调查儿科患者的肠道微生物组成和功能变化.
- 评估肠道微生物群的稳定性和弹性.
主要方法:
- 在四个时间点对来自19名儿科患者的76个样本进行了基因组学分析.
- 时间点:准备前,结肠镜后,2周和准备后4周.
主要成果:
- 香农多样性在结肠镜检查后显著下降,恢复了两周.
- 在特定的属 (例如,Eubacterium,Escherichia) 和物种 (例如,大肠杆菌,B. fragilis) 中观察到显著的变化.
- 五个功能途径显示出显著的变化,在两周后恢复.
结论:
- 分剂量PEG肠道制备剂影响儿科肠道微生物群在属,物种和功能层面.
- 肠道微生物群表现出弹性,在两周内观察到恢复.
- 属级微生物群没有受到影响,这表明特定的微生物群体稳定性.
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