在结直肠癌中,epCAM表达负面调节E-cadherin功能
Uchenna Simon Ezenkwa1,2, Gabriel Olabiyi Ogun3, Mbwas Isaac Mashor4
1Federal Medical Centre Azare, Azare 751101, Bauchi, Nigeria.
Ecancermedicalscience
|August 3, 2023
概括
尼日利亚结直肠癌 (CRC) 患者表现出高表皮细胞粘附分子 (EpCAM) 的过度表达,通常与降低的E-cadherin有关. 这一发现支持针对符合条件的CRC患者的针对性EpCAM疗法.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 结肠直肠癌 (CRC) 在全球范围内是一个重大的健康问题.
- 表皮细胞粘附分子 (EpCAM) 是一种涉及癌症进展的跨膜蛋白.
- 了解不同患者群体中的EpCAM表达对于开发向治疗至关重要.
研究的目的:
- 描述尼日利亚结直肠癌 (CRC) 患者的EpCAM表达模式.
- 为了研究EpCAM和E-cadherin表达之间的关联.
- 为了将EpCAM表达与瘤特征和患者结局相关联,以便选择潜在的抗EpCAM疗法.
主要方法:
- 对CRC组织的组织微阵列和非癌症边缘进行了EPCAM和E-cadherin的染色.
- 抗体染色的得分是半定量的.
- 结果与临床病理学参数 (年龄,性别,瘤阶段) 相对相关.
主要成果:
- 在57.1%的CRC组织中,EPCAM过度表达,其中83%的阳性病例显示过度表达.
- 在19%的组织中,E-cadherin表达是阳性的.
- 过度表达EpCAM显著与减少E-cadherin表达 (p < 0.035) 和增加瘤相关淋巴细胞 (p < 0.02) 相关.
结论:
- 在这个队列中,结肠直肠癌优先过度表达EpCAM而不是E-cadherin.
- 由于EpCAM过度表达而导致细胞-细胞粘附的削弱可能会导致瘤扩散.
- 观察到的免疫反应和EpCAM过度表达支持在符合条件的患者中向抗EpCAM治疗的潜力.
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