黑色石膏中微观结构的首次发现及其性能特征
Yingpeng Li1, Ting Zhu2,3, Jingxian Liang2
1College of Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, People's Republic of China.
Drug design, development and therapy
|August 3, 2023
概括
黑色石膏是一种传统的中医药,在各种温度下保持其结构和功能. 古皮高表现出温度依赖的孔径大小,这对于其缓释特性至关重要.
科学领域:
- 传统中国医药 传统中国医药
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 黑石膏是中国医学的传统外部剂量形式,自古以来一直使用.
- 古皮高是一种具有代表性的黑色石膏膏,具有长期外部应用的历史.
- 这项研究研究了使用Goupi Gao作为模型的黑色石膏剂型的科学特征.
研究的目的:
- 用场发射扫描电子显微镜 - 图像处理 (FESEM-IPP) 来描述黑色石膏的微观结构.
- 分析不同温度下Goupi Gao中活性成分的释放行为.
- 为了评估温度对黑色石膏物理性质的影响.
主要方法:
- 建立了FESEM-IPP以对黑色石膏微结构进行形态和定量表征.
- 在28°C,35°C和45°C的温度下,Goupi Gao的释放经过了研究,采用了盘上的方法.
- 使用超高性能液态染色学 (UPLC) 分析了甲和欧原醇含量.
主要成果:
- 皮高和空白矩阵形成了一个双连续相系统,由油和肥晶体纤维组成.
- 毛孔面积随着温度 (28°C: 216.8±59.5μm2, 35°C: 259.7±52.8μm2, 45°C: 408.0±57.7μm2) 的增加而显著增加.
- 在不同温度的其他孔隙参数中没有观察到显著差异.
结论:
- 黑色石膏的独特结构支持其在各种药物中的应用.
- 黑色石膏具有有利的缓释特性,在极端温度下表现良好.
- 剂型表现出良好的附着性和剥离特性.
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