相关实验视频
Updated: Jul 20, 2025

14:33
The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow
Published on: May 6, 2010
42.0K
普雷克辛D1信号控制新生儿神经元的特定领域的树突发育,在产后的嗅觉球泡
Masato Sawada1,2, Ayato Hamaguchi1, Naomichi Mano1
1Department of Developmental and Regenerative Neurobiology, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Frontiers in neuroscience
|August 3, 2023
概括
塞马3E-PlexinD1-RhoJ通路控制着嗅球中的新生儿神经元如何生长为树突. 这种信号轴确保了特定的树突分支模式,这对神经元发育和功能至关重要.
科学领域:
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
- 发展生物学 发展生物学
背景情况:
- 嗅球中的新生儿神经元迁移并发展出复杂的树突结构.
- 控制树突发育和域特定分支的精确机制在很大程度上是未知的.
研究的目的:
- 为了研究Sema3E-PlexinD1信号传递在调节新生儿神经元在产后嗅觉球中的树突发育中的作用.
- 阐明在特定领域的树突形成背后的分子机制.
主要方法:
- 在嗅球新生儿颗粒细胞中,Sema3E或PlexinD1的遗传移除.
- 过度表达PlexinD1,以评估其对树突分支的影响.
- 分析RhoJ表达及其在树突发育中的参与.
主要成果:
- 对Sema3E或PlexinD1的遗传去除导致了近端顶端树突中树突分支的增加.
- 普雷克辛D1过度表达抑制了近端树突分支以Rho结合域依赖的方式.
- 发现小GTPase RhoJ参与抑制近端分支.
结论:
- Sema3E-PlexinD1-RhoJ信号轴在调节新生儿嗅球神经元中域特异性树突形成方面发挥着关键作用.
- 这一途径对于控制神经元成熟期间树树的空间组织至关重要.
关键词:
在PlexinD1中使用PlexinD1.这就是RhoJJ.树突 (dendrites) 是一种树突.新生儿的神经元新生儿的神经元嗅觉灯泡是一种嗅觉灯泡.产后的神经发生.腹腔 - 腹腔下部区域.更多相关视频
相关概念视频
Olfaction
44.5K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
The olfactory receptors are embedded in the cilia of the...
44.5K
Olfactory Receptors: Location and Structure
9.4K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
9.4K
Physiology of Smell and Olfactory Pathway
8.7K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
The olfactory...
8.7K

