针对乳腺癌治疗中的黄素的向药物输送系统
Mian Huang1, Bing-Tao Zhai1,2, Yu Fan3
1School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, 712046, People's Republic of China.
International journal of nanomedicine
|August 3, 2023
概括
黄素 (CUR) 显示出作为乳腺癌治疗的希望,但面临生物可用性挑战. 基于纳米材料的向药物递送系统 (TDDS) 为增强CUR提供了一个解决方案.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 纳米技术纳米技术
背景情况:
- 乳腺癌 (BC) 是女性癌症相关死亡的主要原因.
- 传统的治疗方法,如化疗和放射治疗,具有显著的副作用.
- 黄中的天然化合物黄 (CUR) 具有抗癌特性,但其生物可用性较差.
研究的目的:
- 审查CUR在乳腺癌中的物理化学特性,生物可用性和抗癌机制.
- 为突出基于CUR的针对性药物递送系统 (TDDS) 在BC治疗中的最新进展.
- 为CUR TDDSs的临床发展提供参考.
主要方法:
- 文献综述,重点关注CUR的特性和BC机制.
- 对CUR各种TDDS的研究分析,包括被动,活性和物理化学方法.
- 强调近期纳米医学研究在BC提供CUR的重点.
主要成果:
- 通过调节细胞内信号通路,CUR显示出抗癌活性.
- 由于CUR的溶解性,稳定性和生物利用性不佳,CUR的治疗潜力受到限制.
- 目前正在开发各种TDDS,包括被动,活性和物理化学,以克服CUR的局限性.
结论:
- 在乳腺癌治疗中,TDDS对于提高CUR的有效性和向性至关重要.
- 基于纳米材料的输送系统为改善CUR治疗指数提供了一个有希望的策略.
- 对CUR TDDS的进一步研究有必要在乳腺癌治疗中进行临床应用.
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