与 lubiprostone 治疗慢性便秘的长期疗效相关的因素
Takashi Morise1, Masakatsu Fukuzawa1, Mitsushige Sugimoto2
1Department of Gastroenterology and Hepatology, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Journal of clinical biochemistry and nutrition
|August 3, 2023
概括
起始剂量为24μg/天的 lubiprostone 有效地治疗日本患者的慢性便秘. 这种低剂量改善了长期的疗效,并减少了恶心和腹等不良事件.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 在日本,慢性便秘的患病率正在上升,影响近20%的人口.
- 老年患者通常需要简单的低剂量治疗,以尽量减少不良事件和多药.
研究的目的:
- 在未经治疗的慢性便秘患者中研究与 lubiprostone 单一治疗的长期疗效相关的因素.
- 为了确定预测 lubiprostone 持续改善的临床特征.
主要方法:
- 74名慢性便秘患者的回顾性评估,这些患者接受了 lubiprostone (24或48μg/天) 治疗.
- 患者特征和持续改善 (≥6个月) 和耐火患者之间的临床结果的比较.
- 多变量分析以确定持续改善的重要预测因素.
主要成果:
- 在6个月的时间里,lubiprostone在76.1%的患者中改善了便秘.
- 每天24μg的起始剂量与持续改善显著相关 (OR:5.791,p=0.046).
- 24微克/天剂量在改善慢性便秘和预防恶心和腹方面表现出有效性.
结论:
- 在日本患者的长期慢性便秘管理中,24μg/天的起始剂量是有效的.
- 较低的lubiprostone初始剂量可以提高治疗坚持性,减少副作用.
- 进一步的研究应该探索在不同患者群体中对 lubiprostone 的最佳剂量策略.
相关概念视频
01:21Drugs for Treatment of Constipation-Predominant IBS
213
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
213
01:22Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives
251
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
251
01:20Drugs Affecting GI Tract Motility: Other Laxatives
276
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
276
01:17Drugs for Treatment of Diarrhea-Predominant IBS
214
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
214
01:23Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
310
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
310
01:17Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents
247
Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
247