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Updated: Jul 20, 2025

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
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克服瘤基因驱动的NSCLC中MET介导的耐药性

Nadine Reischmann1, Carolin Schmelas1, Miguel Ángel Molina-Vila2

  • 1The Healthcare Business of Merck KGaA, Darmstadt, Germany.

iScience
|August 3, 2023
PubMed
概括

在非小细胞肺癌 (NSCLC) 中,MET过度表达会导致对向治疗的耐药性. 将向疗法与MET或SHP2抑制剂结合起来,可以有效地克服各种NSCLC亚型中的这种抗性.

关键词:
癌症 癌症 癌症 癌症卫生科学 卫生科学分子生理学分子生理学

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